Skip to content

Double-Strength SAM-e 400 mg

Doctor's BestUpdated April 2026

This product has been discontinued. Label data shown is from the last available version.

View current version →

Product Information

Form
Tablet or Pill
Servings Per Container
60
UPC
7 53950 00252 4
Product Type
Non-Nutrient/Non-Botanical
DSLD Entry Date
2019-05-28

Target Groups

VegetarianAdult (18 - 50 Years)Gluten Free

All Ingredients

IngredientAmount% DV
SAM-e400 mg

† Daily Value not established.

Label Statements

Formula re: Contains

Doctor’s Best SAM-e helps replenish your SAM-e levels and promote a healthy mood. SAM-e (S-Adenosyl-L-Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody. Supplementing with SAM-e Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate biochemical activity in the human body.

Formula re: Contains

SAM-e and Mood and Cognitive Function SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such as serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body’s antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function.

Formula re: Contains

SAM-e and Joint Function In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue.

Formula re: Contains

SAM-e and Liver Function SAM-e helps support healthy levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Brand IP Statement(s) re: (c), (TM), (SM)

Soloesse is a registered trademark of Gnosis SpA.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s) re: (c), (TM), (SM)

Science-Based Nutrition

Formula re: Contains

Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e providing slow and targeted release for improved GI tolerance and absorption. Our Double-Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.

General: Product/Version Code

YDRB252-2

FDA Statement of Identity

Dietary Supplement

General Statements: All Other Content

Helps support mood and neural function Helps support joint comfort and mobility Helps support liver health and detoxification

Seals/Symbols

Vegetarian

Formulation re: Vegetarian/Vegan

Vegetarian

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 tablet daily between meals, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.

Precautions re: All Other

Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe.

Precautions re: Pregnant or Nursing or Prescription Medications

Do not use if pregnant or nursing.

Precautions re: All Other

May cause gastrointestinal discomfort in a small percentage of people.

Formulation re: Does NOT Contain

Non-GMO Gluten free Soy free

Storage

Store in a cool dry place.

General Statements: All Other Content

Double Strength SAM-e is sealed in blister packs for freshness and stability.

Precautions re: All Other

Do not chew or crush tablet.

Supplement Facts Panel

Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 60
Amount Per Serving% Daily Value*
SAM-e
400 mg

* Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.

Find on Amazon

Similar Products