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SAMe 400

Jarrow FormulasUpdated April 2026
OTHER INGREDIENTS
  • Magnesium stearate
  • Silicon dioxide

Product Information

Form
Tablet or Pill
Servings Per Container
60
UPC
7 90011 20042 0
Product Type
Non-Nutrient/Non-Botanical
DSLD Entry Date
2024-05-23

Target Groups

VeganVegetarianAdult (18 - 50 Years)Women (not pregnant or lactating)No AllergiesGluten FreeDairy Free

All Ingredients

IngredientAmount% DV
S-Adenosyl Methionine400 mg

† Daily Value not established.

Label Statements

Formula re: Contains

Naturally Derived SAMe 400 Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate.

Formulation re: Other

SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Formula re: Contains

With more of the Biologically Active S,S than R,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. SAMe supports: Brain Metabolism and Mood SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes. It has also been proposed to be involved in the formation or metabolism of neurotransmitters, which helps to support a balanced mood. Joint Health SAMe supports the production of healthy connective tissue through transsulfuration. In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage. Liver Function SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.

Formulation re: Does NOT Contain

Jarrow Formulas SAMe is made by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAMe.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula re: Contains

Naturally derived SAMe 400 S-adenosyl methionine Active S,S form Extra strength

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.

Formula re: Contains

Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and provides 400 mg S-Adenosyl Methionine derived from 800 mg of SAMe Tosylate Disulfate.

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: Do not use if pregnant or nursing.

Precautions re: All Other

Individuals with Parkinson’s disease, bi-polar disorder, or manic depression should not use this product. May cause gastrointestinal upset in some persons.

Precautions re: Children

Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use. Keep out of the reach of children.

Precautions re: Pregnant or Nursing or Prescription Medications

Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.

Storage

Store in a cool, dry place.

Precautions re: All Other

Do not use if safety seal or blister is broken, damaged or missing.

Formulation re: Vegetarian/Vegan

Vegan

Formula re: Contains

400 mg (net yield) SAMe from 800 mg SAMe tosylate disulfate Enteroguard coating

Formulation re: Other

Extra strength Supports balanced mood, joint health, and liver function In foil blister pack

Formulation re: Does NOT Contain

Gluten free

FDA Statement of Identity

Dietary Supplement

Formulation re: Does NOT Contain

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.

Formula re: Contains

EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.

Brand IP Statement(s) re: (c), (TM), (SM)

Copyright 2023 Jarrow Formulas

General Statements: All Other Content

Mood support

Supplement Facts Panel

Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 60
Amount Per Serving% Daily Value*
S-Adenosyl Methionine
400 mg

* Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.

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