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SAMe 400 mg

Jarrow FormulasUpdated April 2026

This product has been discontinued. Label data shown is from the last available version.

Product Information

Form
Tablet or Pill
Servings Per Container
30
UPC
7 90011 20020 8
Product Type
Non-Nutrient/Non-Botanical
DSLD Entry Date
2019-04-25

Target Groups

VeganVegetarianAdult (18 - 50 Years)Gluten FreeDairy Free

All Ingredients

IngredientAmount% DV
S-Adenosyl Methionine400 mg

† Daily Value not established.

Label Statements

Formula re: Contains

S-Adenosyl Methionine

General Statements: All Other Content

Full potency

Suggested/Recommended/Usage/Directions

Usage: Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product.

Precautions re: All Other

Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAMe.

Precautions re: Pregnant or Nursing or Prescription Medications

Do not use if pregnant or nursing.

Precautions re: All Other

Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Precautions re: All Other

Jarrow Fomulas SAMe 400 is foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.

Formula re: Contains

Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate.

Brand IP Statement(s) re: (c), (TM), (SM)

For best results, use the Jarrow Formulas JarroSil, the biologically Activated Silicon.

Storage

Store in a cool, dry place.

Precautions re: Children

Keep out of the reach of children.

General Statements: All Other Content

In Foil Blister Pack

Brand IP Statement(s) re: (c), (TM), (SM)

New pH-Sensitive Food-grade Enteroguard coating

Formula re: Contains

S-Adenosyl Methionine 400 mg (net yield) SAMe from 800 mg SAMe Tosylate Disulfate Highest Concentration of Active S,S Form

General Statements: All Other Content

Promotes: Joint Strength Liver Detoxification Mood and Brain Function Enteric-Coated Tablets

Seals/Symbols

Gluten free Vegan V

FDA Statement of Identity

Dietary Supplement

Formulation re: Vegetarian/Vegan

Suitable for Vegetarians/Vegans.

Formulation re: Does NOT Contain

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

Brand IP Statement(s) re: (c), (TM), (SM)

EnteroGuard is a proprietary cellulose based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.

General: Product/Version Code

11516SAM400 PROD # 120020

Brand IP Statement(s) re: (c), (TM), (SM)

2016 Jarrow Formulas

Formula re: Contains

Natural SAMe 400 Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.

Formula re: Contains

SAMe has been clinically shown to have the following benefits: Joint Strength SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin). Liver SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body's endogenous antioxidant network and important for liver function, including phase II detoxification.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Supplement Facts Panel

Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 30
Amount Per Serving% Daily Value*
S-Adenosyl Methionine
400 mg

* Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.

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