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SAMe Joint

Jarrow FormulasUpdated April 2026

This product has been discontinued. Label data shown is from the last available version.

Product Information

Form
Tablet or Pill
Servings Per Container
60
UPC
7 90011 20019 2
Product Type
Non-Nutrient/Non-Botanical
DSLD Entry Date
2019-05-28

Target Groups

VeganVegetarianAdult (18 - 50 Years)Gluten FreeDairy Free

All Ingredients

IngredientAmount% DV
Glucosamine HCl525 mg
S-Adenosyl Methionine200 mg

† Daily Value not established.

Label Statements

Formula re: Contains

SAMe + Glucosamine

General Statements: All Other Content

Full potency

Suggested/Recommended/Usage/Directions

Usage: Take 1 tablet 1 or 2 times per day on an empty stomach or as directed by your qualified healthcare professional.

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using this product.

Precautions re: All Other

Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAMe.

Precautions re: Pregnant or Nursing or Prescription Medications

Do not use if pregnant or nursing.

Precautions re: All Other

Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.

Precautions re: All Other

Jarrow Formulas SAMe Joint is foil blister-packed to maximize stability and safety. Do not use if seal of blister pack is broken.

Formula re: Contains

Full potency 200 mg SAMe (net yield) is derived from 400 mg of SAMe tosylate disulfate.

Formulation re: Does NOT Contain

Jarrow Formulas Glucosamine HCl is a sodium free form of glucosamine.

General Statements: All Other Content

For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.

Storage

Store in a cool, dry place.

Precautions re: Children

Keep out of the reach of children.

Formula re: Contains

S-Adenosyl Methionine + Glucosamine 200 mg (net yield) SAMe 525 mg Glucosamine HCl Highest Concentration of Active S,S Form

General Statements: All Other Content

Promotes: Joint Strength Liver Detoxification Mood and Brain Function Enteric-Coated Tablets

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Vegan V

Formulation re: Vegetarian/Vegan

Suitable for Vegetarians/Vegans.

Formulation re: Does NOT Contain

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, or peanuts/tree nuts.

General Statements: All Other Content

This product complies with the proposed USP Monograph for SAMe.

General: Product/Version Code

04318SAMJNT PROD # 120019

Brand IP Statement(s) re: (c), (TM), (SM)

2018 Jarrow Formulas

Formula re: Contains

Natural SAMe Joint Jarrow Formulas SAMe Joint provides a full 200 mg SAMe (net yield) and 525 mg of glucosamine hydrochloride in every enteric-coated tablet. SAMe Joint is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. SAMe and glucosamine are known to benefit joint function and recuperation. Contains More of the Active S,S Form SAMe Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formula SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available. Glucosamine Glucosamine is an aminosaccharide synthesized by transamidase enzymes from glucose and an amine group from glutamine. HCl (hydrochloric acid) stabilizes the glucosamine in this product. Glucosamine is a component of joint and intestinal tissue and is involved in the production of synovial fluid that lubricates the joints. SAMe has been clinically shown to have the following benefits: Joint Strength SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin). Liver SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body's endogenous antioxidant network and important for liver function, including phase II detoxification.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Supplement Facts Panel

Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 60
Amount Per Serving% Daily Value*
Glucosamine HCl
525 mg
S-Adenosyl Methionine
200 mg

* Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.

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