Skip to content

Double-Strength SAMe 400

Doctor's BestUpdated April 2026

Product Information

Form
Tablet or Pill
Servings Per Container
60
UPC
7 53950 00252 4
Product Type
Non-Nutrient/Non-Botanical
DSLD Entry Date
2013-09-25

Target Groups

VegetarianAdult (18 - 50 Years)Gluten FreeDairy Free

All Ingredients

IngredientAmount% DV
S-Adenosyl Methionine400 mg

† Daily Value not established.

Label Statements

General Statements: All Other Content

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Mehtylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

General Statements: All Other Content

Supplementing with SAMe The manufacturing process of SAMe yields two forms, the S,S and R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

General Statements: All Other Content

SAMe and Joint Function SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential somponents of connective tissue. Clinical studies show and ability of SAMe to enhance mobility and movement, and promote joint comfort.

General Statements: All Other Content

SAMe and Neural Health SAMe-catalyzed methylation reactions promote he symthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidycholine, supporting cognitive function.

General Statements: All Other Content

SAMe and Liver Function SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula re: Contains

Our Double-Strength SAMe 400 contains 400mg of active SAMe in each tablet.

General Statements: All Other Content

Doctor's Best utilizes only the highest quality Italian SAMe available on e market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

Storage

Double-Strength SAMe is sealed in blister packs for freshness and stability. Store product in a cool, dry place to ensure maximum quality.

Brand IP Statement(s) re: (c), (TM), (SM)

Science-Based Nutrition(TM)

FDA Statement of Identity

Dietary Supplement with 400mg Active S-Adenosyl Methionine Per Tablet

Formula re: Contains

Dietary Supplement with 400mg Active S-Adenosyl Methionine Per Tablet

General Statements: All Other Content

Enhances Mood & Neural Function Promotes Joint Comfort & Mobility Supports Liver Health & Detoxification Pharmaceutical Grade Made in Italy

Storage

Sealed in Blister Packs for Freshness & Convenience

Suggested/Recommended/Usage/Directions

Suggested Adult Use: Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.

Precautions re: Pregnant or Nursing or Prescription Medications

Individuals using antidepressant medications should consult with their prescribing physician prior to using this product.

Precautions re: All Other

Individuals diagnosed wit bipolar disease or manic depression should avoid supplementing with SAMe.

Precautions re: Pregnant or Nursing or Prescription Medications

Do not use if pregnant or nursing.

Precautions re: All Other

May cause gastrointestinal discomfort is a small percentage of people.

Formulation re: Does NOT Contain

The SAMe found in Doctor's Best SAMe 400mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat, and artificial flavoring.

Formulation re: Vegetarian/Vegan

Suitable for Vegetarians

General Statements: All Other Content

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

General: Product/Version Code

P 03/11

Supplement Facts Panel

Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 60
Amount Per Serving% Daily Value*
S-Adenosyl Methionine
400 mg

* Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.

Find on Amazon

Similar Products