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SAMe 400 mg

Source NaturalsUpdated April 2026

Product Information

Form
Tablet or Pill
Servings Per Container
30
UPC
0 21078 01400 3
Product Type
Non-Nutrient/Non-Botanical
DSLD Entry Date
2017-04-25

Target Groups

VegetarianAdult (18 - 50 Years)Gluten FreeDairy FreeSugar Free

All Ingredients

IngredientAmount% DV
SAMe400 mg

† Daily Value not established.

Label Statements

Formula re: Contains

Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine.

General Statements: All Other Content

These tablets are enteric coated and blister packed for consistent quality and optimal bioactivity. SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. A number of clinical studies have demonstrated that SAMe supplementation supports joint comfort, function and mobility in the spine, hips and knees. Preliminary research suggests that SAMe may work by supporting the production of proteoglycans, which are important components of cartilage. Numerous clinical studies have also demonstrated that SAMe can help support a positive outlook. It is able to cross the blood-brain barrier, where it is thought to affect the synthesis of neurotransmitters, and to help maintain normal membrane fluidity. SAMe works together with the B-vitamins, in particular folic acid, making it important to obtain adequate amounts of the B-vitamin complex from diet and supplements. SAMe plays a key role in transmethylation, a vital type of chemical reaction that affects the synthesis, activation, and metabolism of various biological molecules. Compounds that require this reaction include phospholipids, which are fundamental for all cell membrane functions and for cell to cell communication.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 tablet 1 to 3 times daily. Take tablets on an empty stomach.

Precautions re: Pregnant or Nursing or Prescription Medications

Warning: If you are pregnant, may become pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product.

Precautions re: All Other

Use this product under medical supervision if you have bipolar disorder. In a small percentage of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.

Precautions re: All Other

Do not use if either tamper-evident seal is broken or missing.

Precautions re: Children

Keep out of the reach of children.

Formulation re: Vegetarian/Vegan

Suitable for vegetarians.

Formulation re: Does NOT Contain

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, preservatives, or artificial flavor or fragrance.

General: Product/Version Code

SN1400 REV K163

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements: All Other Content

Supports joint comfort, function and mobility

FDA Statement of Identity

Dietary Supplement

General Statements: All Other Content

Double strength

Formula re: Contains

S-adenosyl-L-methionine

Supplement Facts Panel

Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 30
Amount Per Serving% Daily Value*
SAMe
400 mg

* Percent Daily Values are based on a 2,000 calorie diet.

† Daily Value not established.

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